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CELEBRATING 20 YEARS OF
BOTOX® COSMETIC

Since FDA approval in 2002, BOTOX® Cosmetic is the #1 selling product of its kind on the market.

The history of BOTOX® Cosmetic is a remarkable story of how a potent substance has been harnessed for both medical and aesthetic benefits.

Years ago, Allergan acquired a product called onabotulinumtoxinA and saw its potential for therapeutic use. The company conducted clinical trials and submitted the data to the FDA, which shepherded the product's first approved therapeutic use.

1989 THE FIRST FDA APPROVAL

OnabotulinumtoxinA received FDA approval for therapeutic use in 1989 and was rebranded BOTOX®. Through expanded research into aesthetic uses Allergan later commenced clinical trials to study the treatment's safety and efficacy for moderate to severe frown lines. Allergan Aesthetics has adhered to rigorous quality and safety requirements for over 30 years.

2002 THE FIRST TREATMENT OF ITS KIND APPROVED

On April 15, 2002, the FDA approved BOTOX® as a temporary cosmetic treatment for moderate to severe frown lines in adults and requested the product be marketed as BOTOX® Cosmetic to distinguish cosmetic from therapeutic uses. It was the first treatment of its kind and today is the only product FDA approved to make moderate to severe frown lines, crow’s feet, and forehead lines look better in adults.

THE ONLY NEUROTOXIN FDA APPROVED FOR 3 TREATMENT AREAS

BOTOX® Cosmetic is the first and only product of its kind that's FDA-approved treatment for the temporary improvement in the appearance of moderate to severe forehead lines, frown lines, and crow's feet in adult patients.

98 COUNTRIES

BOTOX® Cosmetic is manufactured to the strict quality standards of 98 different countries and has become the #1 selling treatment of its kind.

100 MILLION VIALS SOLD**

Today, the community of patients receiving BOTOX® Cosmetic continues to grow, with approximately 100 million vials sold in the United States alone since 2002.

4700 PEER-REVIEWED ARTICLES

The safety and effectiveness profile of BOTOX® Cosmetic has been featured in more than 16 years of published research and described in 4700 articles in peer-reviewed scientific and medical journals. BOTOX® Cosmetic has become the most widely researched and studied treatment of its kind.

BOTOX® COSMETIC CELEBRATES 20 YEARS

*Data collected through 2022.

**With 100M vials of both BOTOX® and BOTOX® Cosmetic sold.

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IMPORTANT SAFETY INFORMATION & APPROVED USES
BOTOX® Cosmetic may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems any time (hours to weeks) after injection
of BOTOX® Cosmetic: Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are
pre-existing before injection. Swallowing problems may last for several months.

IMPORTANT SAFETY INFORMATION & APPROVED USES
BOTOX® Cosmetic may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems any time (hours to weeks) after injection of BOTOX® Cosmetic:

  • Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.
  • Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing.

BOTOX® Cosmetic dosing units are not the same as, or comparable to, any other botulinum toxin product.

There has not been a confirmed serious case of spread of toxin effect when BOTOX® Cosmetic has been used at the recommended dose to treat frown lines, crow’s feet lines, and/or forehead lines.

BOTOX® Cosmetic may cause loss of strength or general muscle weakness, vision problems, or dizziness within hours to weeks of taking BOTOX® Cosmetic. If this happens, do not drive a car, operate machinery, or do other dangerous activities.

Serious and/or immediate allergic reactions have been reported. They include: itching, rash, red itchy welts, wheezing, asthma symptoms, or dizziness or feeling faint. Get medical help right away if you are wheezing or have asthma symptoms, or if you become dizzy or faint.

Do not receive BOTOX® Cosmetic if you : are allergic to any of the ingredients in BOTOX® Cosmetic (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as Myobloc® (rimabotulinumtoxinB), Dysport® (abobotulinumtoxinA), or Xeomin® (incobotulinumtoxinA); have a skin infection at the planned injection site.

Tell your doctor about all your muscle or nerve conditions, such as ALS or Lou Gehrig’s disease, myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of serious side effects including difficulty swallowing and difficulty breathing from typical doses of BOTOX® Cosmetic.

Tell your doctor about all your medical conditions, including: plans to have surgery; had surgery on your face; have trouble raising your eyebrows; drooping eyelids; any other abnormal facial change; are pregnant or plan to become pregnant (it is not known if BOTOX® Cosmetic can harm your unborn baby); are breast-feeding or plan to (it is not known if BOTOX® Cosmetic passes into breast milk).

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using BOTOX® Cosmetic with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received BOTOX® Cosmetic in the past.

Tell your doctor if you have received any other botulinum toxin product in the last 4 months; have received injections of botulinum toxin such as Myobloc®, Dysport®, or Xeomin® in the past (tell your doctor exactly which product you received); have recently received an antibiotic by injection; take muscle relaxants; take an allergy or cold medicine; take a sleep medicine; take aspirin-like products or blood thinners.

Other side effects of BOTOX® Cosmetic include : dry mouth; discomfort or pain at the injection site; tiredness; headache; neck pain; and eye problems: double vision, blurred vision, decreased eyesight, drooping eyelids and eyebrows, swelling of your eyelids and dry eyes.

APPROVED USES
BOTOX® Cosmetic is a prescription medicine that is injected into muscles and used to temporarily improve the look of moderate to severe forehead lines, crow’s feet lines, and frown lines between the eyebrows in adults.

For more information refer to the Medication Guide or talk with your doctor.

To report a side effect, please call Allergan at 1-800-678-1605.

Please see BOTOX® Cosmetic full Product Information including Boxed Warning and Medication Guide.

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